Jürgen Frevert, BSc, PhD
Z. Paul Lorenc, MD, FACS
Corey Maas, MD, FACS


Course Details

Course Description/Purpose:

This course has been developed to provide clarity surrounding the presence of complexing proteins in BotulinumtoxinA (BoNT-A) products and the impact they may have on product performance.  In this course, the faculty will review the science regarding BoNT-A complexing proteins and their impact on product stability, therapeutic effect, and nonresponse.

In addition, an overview of the multiple recent studies on BoNT-A dose escalation will be provided. The relationship between BoNT-A dose and duration of effect will be discussed, as well as the data surrounding safety. How these data may be applied to clinical practice for the benefit of patients will also be discussed. 

To complete this activity and receive credit, the participant should:

  • Review the materials on accreditation information, target audience, learning objectives, and disclosure information
  • Complete the entire self-study
  • Complete the post-test and evaluation/claim form


Jointly Provided by:

Educational Objectives

Upon completion of this activity, participants should be able to:

  • Describe the function of BotulinumtoxinA complexing proteins in nature, as well as their role and impact  in FDA approved BoNT-A products, as demonstrated in scientific studies.
  • Identify the relative amounts of complexing proteins in FDA approved BoNT-A products
  • Describe the relative potencies of BoNT-A products, as well as the factors that may influence measures of potency
  • Describe the research surrounding BoNT-A dose escalation, including the impact of dose escalation on safety and efficacy/duration. 

Commerical Support Acknowledgement

Support for this educational activity is provided by Merz.  


Target Audience

This CME-certified activity is primarily intended and designed to educate cosmetic surgeons, dermatologists, facial plastic surgeons, oculoplastic surgeons, plastic surgeons, and those who assist in their practice.


Continuing Education

In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME), Imedex, and xMedica. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians:  This activity has been approved for AMA PRA Category 1 Credit™.

NACCME designates this enduring activity for a maximum of 2.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


The information contained during this course is for educational purposes only and may not apply to your specific application or situation. The course content is not verified and should not be relied on for any medical or experimental procedures. Additional education is required to compliment the information contained therein. The author, society, distributor and provider (hereinafter referred to as the "Producers") shall not be liable for any loss, injury or damages, including without limitation any indirect or consequential damage or injury, resulting from the implementation of the practices and research discussed or displayed in the course. As a result of viewing this course, you agree that reliance on any practice displayed in the course without additional research, verification, and study shall be at your own risk. The Producers accept no liability for the content of this course.


Equal Opportunity

Events, activities, programs and facilities of NACCME and Imedex are available to all without regard to race, color, marital status, gender, sexual orientation, religion, national origin, disability, age, Vietnam or disabled veteran status as provided by law and in accordance with the company's respect for personal dignity.


Privacy Statement

NACCME protects the privacy of personal and other information regarding participants, educational partners and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the customer's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.


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